I am an Assistant Professor Cell Biology, Development, and Physiology at the University of California, Berkeley. My laboratory uses basic and systems cell biology approaches to interrogate the mechanisms of mitochondrial genome synthesis, segregation and inheritance in animal cells.
Dr. Lewis’ research investigates how animal cells ensure the continual energy supply they need to survive, and how this goes awry in human disease. Her laboratory team focuses on mitochondria, the “powerhouse of the cell”, which harbor their own genomic blueprint called mitochondrial DNA. Dr. Lewis’ experimental approach leverages live microscopy at high spatial and temporal resolution, single-cell analyses of DNA replication and transcription, gene editing, proteomics, and genetics to reveal how cells replicate, segregate, and inherit this “neglected genome”.
The Lewis Lab is also affiliated with: